This is the first and only approved antidote for apixaban- or rivaroxaban-treated patients with uncontrolled bleeding. ![]() The European Medicines Agency (EMA), Europe, on Apunder conditional marketing authorisation under the brand name Ondexxya (andexanet alfa).The Food and Drug Administration (FDA), USA, with accelerated approval on May 3, 2018.Where has Andexxa (coagulation factor Xa (recombinant), inactivated-zhzo) been approved?Īndexxa (coagulation factor Xa (recombinant), inactivated-zhzo) was approved for the reversal of the anticoagulating effects of rivaroxaban and apixaban in patients with life-threatening or uncontrolled bleeding by: Hereby it is able to rapidly reverse their blood-thinning effect, and to stop bleeding. It works by binding and sequestering FXa inhibitors, making them unable to promote anticoagulation. Īndexxa (coagulation factor Xa (recombinant), inactivated-zhzo) is a recombinant protein that has been designed to bind to FXa inhibitors. However, a complication of treatment with these anticoagulants is major bleeding. FXa is a protein that helps blood clot, and its inhibitors are used to have an anticoagulant (blood-thinning) effect. Thromboembolism is obstruction in vessels due to formation of blood clots. How does Andexxa (coagulation factor Xa (recombinant), inactivated-zhzo) work?įactor Xa (FXa) inhibitors such as apixaban and rivaroxaban are widely used in the clinic to prevent and to treat thromboembolism. It is available in lyophilized powder form in single-use vials of 200 mg or 100 mg of coagulation factor Xa (recombinant), inactivated-zhzo. What is Andexxa (coagulation factor Xa (recombinant), inactivated-zhzo) for?Īndexxa (coagulation factor Xa (recombinant), inactivated-zhzo), is a Factor Xa inhibitor reversal agent indicated for patients treated with rivaroxaban and apixaban, when rapid reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |